Chris Froome, Alberto Contador, and Alejandro Valverde can all ride into the record books at the Vuelta, which begins Saturday.
Quintana finished fourth in the 2015 Vuelta and Valverde won the 2009 edition of the Spanish race.
Nairo Quintana has yet to make a race-changing move in this Tour, which leaves some wondering if he has the legs to do so.
Multiple teams came to the Tour de France with more than one GC option, but potential conflicts have fizzled out.
Despite having multiple grand tour victories between them, Vincenzo Nibali and Alejandro Valverde are lining up for this year's Tour as
In closing out the 2016 Giro d'Italia third overall, Alejandro Valverde now counts podium finishes in all three grand tours
The Giro d'Italia's final standings will be decided in two short Alpine stages where Chaves, Valverde, and Nibali all promise to attack.
Alejandro Valverde collects his first Giro stage win, but the real surprise comes from Steven Kruijswijk who consolidates overall lead.
The Giro's 15th stage serves up a reversal of fortunes for Alejandro Valverde and Vincenzo Nibali
Movistar struggles through the Giro's decisive stage 14