The reigning world champion breaks free from the leading group inside the final kilometer to win the stage.
With eight of the 17 rounds in the books, the UCI WorldTour heads to Philadelphia for the International Cycling Classic.
Wednesday's Flèche Wallonne ends on the famed Mur de Huy, and the puncheurs of the peloton will be there fighting for a win.
Boels riders collected buckets of wins in 2015, and Lizzie Armitstead won the overall World Cup title.
Great Britain's Lizzie Armitstead won the women's world road championship Saturday in Richmond; American Megan Guarnier finished third
The cycling world will turn its attention to Richmond, Virginia starting this weekend at the UCI Road World Championships.
The Boels-Dolmans rider was on the ground for more than 30 minutes before paramedics took her away in an ambulance
Breakaways tried and failed, and in the end it was Lizzie Armitstead out-kicking a large group charging up the Manayunk Wall
Flèche Wallonne organizers added a new climb near the finish of Wednesday's race, but the race could still be decided on the Mur de Huy
In the absence of five-time winner Vos, all eyes will be on world champ Ferrand-Prévot who faces challenges from several big names